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iFluor™ 488 TCO

英文名称:iFluor® 488 TCO
iFluor™ 488 TCO
价格 2683
产品规格
1 mg

产品货号
产品参数
Ex (nm)491Em (nm)516
分子量945.16溶剂DMSO
存储条件在零下15度以下保存, 避免光照
产品概述

产品基本信息

产品名称:iFluor™ 488 TCO

储存条件:-15℃避光防潮

保质期:12个月

 

产品物理化学光谱特性

分子量:856.79

外观:固体

溶剂:DMSO

Ex(nm):491

Em(nm):516

 

产品介绍

四嗪-反式-环辛烯(TCO)的连接构成了快速的生物分子标记方法。四嗪功能化的分子与TCO功能化的分子反应,通过二氢吡嗪部分形成稳定的结合物。由于其极快的动力学,它已获得普及。AAT Bioquest提供了一组含四嗪和TCO的染料,用于探索可以利用这种强大点击反应的各种生物系统。iFluor™488-TCO可以轻松用于标记四嗪改性的生物分子,用于荧光成像和其他基于荧光的生化分析。与荧光素衍生物(例如FITC)的缀合物相比,使用iFluor™488染料制备的缀合物要优越得多。iFluor™488缀合物比荧光素缀合物明显更亮,并且光稳定性更高。此外,iFluor™488的荧光不受pH(4-10)的影响。这种pH不敏感性是对荧光素的一个重大改进,荧光素仅在pH高于9时才发出大荧光。iFluor™488具有类似于AlexaFluor®488的光谱特性,在某些情况下,它显示出更明亮的信号(AlexaFluor®是Invitrogen的商标)。

点击查看光谱

 

参考文献

A General Strategy for Macrotheranostic Prodrug Activation: Synergy between the Acidic Tumor Microenvironment and Bioorthogonal Chemistry.
Authors: Dong, Yansong and Tu, Yalan and Wang, Kewei and Xu, Congfei and Yuan, Youyong and Wang, Jun
Journal: Angewandte Chemie (International ed. in English) (2020): 7168-7172

A Pretargeted Imaging Strategy for Immune Checkpoint Ligand PD-L1 Expression in Tumor Based on Bioorthogonal Diels-Alder Click Chemistry.
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Journal: Molecular imaging and biology (2020): 842-853

A Systematic Study of Coumarin-Tetrazine Light-Up Probes for Bioorthogonal Fluorescence Imaging.
Authors: Galeta, Juraj and Dzijak, Rastislav and Obořil, Jan and Dračínský, Martin and Vrabel, Milan
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)

A colorimetric immunosensor for determination of foodborne bacteria using rotating immunomagnetic separation, gold nanorod indication, and click chemistry amplification.
Authors: Guo, Ruya and Huang, Fengchun and Cai, Gaozhe and Zheng, Lingyan and Xue, Li and Li, Yanbin and Liao, Ming and Wang, Maohua and Lin, Jianhan
Journal: Mikrochimica acta (2020): 197

Antibody Pretargeting Based on Bioorthogonal Click Chemistry for Cancer Imaging and Targeted Radionuclide Therapy.
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Journal: Bioconjugate chemistry (2020): 159-173

Bioorthogonal Tetrazine Carbamate Cleavage by Highly Reactive trans-Cyclooctene.
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Bond-Breaking Bio-orthogonal Chemistry Efficiently Uncages Fluorescent and Therapeutic Compounds under Physiological Conditions.
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Journal: Organic letters (2020): 6041-6044

Bridge-Clamp Bis(tetrazine)s with [N]8 π-Stacking Interactions and Azido-s-Aryl Tetrazines: Two Classes of Doubly Clickable Tetrazines.
Authors: Mboyi, Clève D and Vivier, Delphine and Daher, Ahmad and Fleurat-Lessard, Paul and Cattey, Hélène and Devillers, Charles H and Bernhard, Claire and Denat, Franck and Roger, Julien and Hierso, Jean-Cyrille
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Cellular Delivery of Bioorthogonal Pretargeting Therapeutics in PSMA-Positive Prostate Cancer.
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Click by Click Microporous Annealed Particle (MAP) Scaffolds.
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Journal: Advanced healthcare materials (2020): e1901391